Achaete-Scute Homolog 1 (ASCL1) Antibody

ACSL1, alternatively titled Hash1 or Mash1, is a member of the basic helix-loop-helix (BHLH) family of transcription factors. It activates transcription by binding to the E box (5'-CANNTG-3'). Dimerization with other BHLH proteins is required for efficient DNA binding. ACSL1 plays a role in the neuronal commitment and differentiation and in the generation of olfactory and autonomic neurons. The protein is highly expressed in medullary thyroid cancer and small cell lung cancer and may be a useful marker for these cancers. The presence of a CAG repeat in the gene suggests it may also play a role in tumor formation.

Target	Achaete-Scute Homolog 1 (ASCL1)
Clonality	Polyclonal
Reactivity	Human, Mouse
Tested Applications	ELISA, WB
Host	Rabbit
Recommended dilutions	WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 166-196 amino acids from the C-terminal region of human ASCL1 (Achaete-scute homolog 1).
Isotype	IgG
Form	Liquid
Purification	Purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P50553 (UniProt, ExPASy)
UniProt Secondary AC	A8K3C4, Q9BQ30
UniProt Entry Name	ASCL1_HUMAN
NCBI Accession	NP_004307.2
KEGG	hsa:429
String	9606.ENSP00000266744
Molecular Weight	Calculated MW: 25.5 kDa
Buffer	PBS containing 0.09% sodium azide.
Specificity	Predicted to react with Rat ASCL1.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Achaete-Scute Homolog 1 (ASCL1)

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