3(2),5-Bisphosphate Nucleotidase 1 (BPNT1) Antibody

BPNT1, also called bisphosphate 3-prime-nucleotidase, or BPntase, is a member of a magnesium-dependent phosphomonoesterase family. Lithium, a major drug used to treat manic depression, acts as an uncompetitive inhibitor of BPntase. The predicted human protein is 92% identical to mouse BPntase. BPntase's physiologic role in nucleotide metabolism may be regulated by inositol signaling pathways. The inhibition of human BPntase may account for lithium-induced nephrotoxicity.

Target	3(2),5-Bisphosphate Nucleotidase 1 (BPNT1)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, WB
Host	Rabbit
Recommended dilutions	WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 277-305 amino acids from the C-terminal region of human BPNT1.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein A column, followed by peptide affinity purification.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	O95861 (UniProt, ExPASy)
UniProt Secondary AC	A8K7C8, B4DPS5, B4DUS9, D3DTA9, Q8WVL5, Q9UGJ3
UniProt Entry Name	BPNT1_HUMAN
Gene Symbol	BPNT1
KEGG	hsa:10380
String	9606.ENSP00000446828
Molecular Weight	Calculated MW: 33.4 kDa
Buffer	PBS containing 0.09% sodium azide.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on 3(2),5-Bisphosphate Nucleotidase 1 (BPNT1)

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