ATP Binding Cassette Subfamily B Member 7 (ABCB7) Antibody

The membrane-associated protein ABCB7 is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. This gene encodes a half-transporter involved in the transport of heme from the mitochondria to the cytosol. With iron/sulfur cluster precursors as its substrates, this protein may play a role in metal homeostasis. Mutations in this gene have been implicated in X-linked sideroblastic anemia with ataxia.

Target	ATP Binding Cassette Subfamily B Member 7 (ABCB7)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, WB, IHC
Host	Rabbit
Recommended dilutions	WB: 1/1000, IHC-P: 1/50 - 1/100. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 718-746 amino acids from the C-terminal region of human ABCB7.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	O75027 (UniProt, ExPASy)
UniProt Secondary AC	G3XAC4, O75345, Q5VWY7, Q5VWY8, Q9BRE1, Q9UND1, Q9UP01
UniProt Entry Name	ABCB7_HUMAN
Gene Symbol	ABCB7
GeneID	22
OMIM	300135
NCBI Accession	NP_001258625.1 NM_001271696.1
HGNC	48
KEGG	hsa:22
Ensembl	ENSG00000131269
String	9606.ENSP00000253577
Molecular Weight	Calculated MW: 82.6 kDa
Buffer	PBS containing 0.09% sodium azide.
Specificity	Predicted to react with Mouse and Rat ABCB7.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on ATP Binding Cassette Subfamily B Member 7 (ABCB7)

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