Broad Substrate Specificity ATP-Binding Cassette Transporter ABCG2 (ABCG2) Antibody

This product is currently in development. The lead time for this product may be several months. Please contact us at [email protected] for an updated lead time before purchasing this product.

This product is currently in development. The lead time for this product may be several months. Please contact us at [email protected] for an updated lead time before purchasing this product.

ABCG2 is a membrane-associated protein included in the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. Alternatively referred to as a breast cancer resistance protein, this protein functions as a xenobiotic transporter which may play a major role in multi-drug resistance. It likely serves as a cellular defense mechanism in response to mitoxantrone and anthracycline exposure. Significant expression of this protein has been observed in the placenta, which may suggest a potential role for this molecule in placenta tissue.

Target	Broad Substrate Specificity ATP-Binding Cassette Transporter ABCG2 (ABCG2)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, WB, IHC, FCM
Host	Rabbit
Recommended dilutions	WB: 1/1000, IHC-P: 1/100 - 1/500, FCM: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 594-623 amino acids from the C-terminal region of human ABCG2 (BCRP).
Isotype	IgG
Form	Liquid
Purification	Purified Rabbit Polyclonal Antibody.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q9UNQ0 (UniProt, ExPASy)
UniProt Entry Name	ABCG2_HUMAN
NCBI Accession	NP_001244315.1 NP_004818.2
String	9606.ENSP00000237612
Molecular Weight	Calculated MW: 72.3 kDa
Buffer	PBS containing 0.09% sodium azide.
Availability	Please enquire.
Note	This product is for research use only.

Research Articles on Broad Substrate Specificity ATP-Binding Cassette Transporter ABCG2 (ABCG2)

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