Acid-Sensing Ion Channel 3 (ACCN3) Antibody

This gene encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, two hydrophobic transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. The member encoded by this gene is an acid sensor and may play an important role in the detection of lasting pH changes. In addition, a heteromeric association between this member and ACCN1 has been observed as proton-gated channels sensitive to gadolinium. Alternative splicing of this gene generates three transcript variants encoding distinct isoforms.

Target	Acid-Sensing Ion Channel 3 (ACCN3)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, WB
Host	Rabbit
Recommended dilutions	WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 55-83 amino acids from the N-terminal region of human ACCN3.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein A column, followed by peptide affinity purification.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q9UHC3 (UniProt, ExPASy)
UniProt Secondary AC	B2R9V0, O60263, O75906, Q59FN9, Q9UER8, Q9UHC4
UniProt Entry Name	ASIC3_HUMAN
Gene Symbol	ASIC3
String	9606.ENSP00000297512
Molecular Weight	Calculated MW: 58.9 kDa
Buffer	PBS containing 0.09% sodium azide.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Acid-Sensing Ion Channel 3 (ACCN3)

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