Angiotensin I Converting Enzyme (ACE) Antibody

This gene encodes an enzyme involved in catalyzing the conversion of angiotensin I into a physiologically active peptide angiotensin II. Angiotensin II is a potent vasopressor and aldosterone-stimulating peptide that controls blood pressure and fluid-electrolyte balance. This enzyme plays a key role in the renin-angiotensin system. Many studies have associated the presence or absence of a 287 bp Alu repeat element in this gene with the levels of circulating enzyme or cardiovascular pathophysiologies. Multiple alternatively spliced transcript variants encoding different isoforms have been identified, and two most abundant spliced variants encode the somatic form and the testicular form, respectively, that are equally active. This antibody is supplied as crude ascites.

Target	Angiotensin I Converting Enzyme (ACE)
Clonality	Monoclonal
Reactivity	Mouse
Tested Applications	ELISA, WB
Host	Mouse
Recommended dilutions	WB: 1/500 - 1/16000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 1274-1306 amino acids from human ACE.
Isotype	IgG2a
Form	Liquid
Purification	Unpurified crude ascites.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P12821 (UniProt, ExPASy)
UniProt Secondary AC	B0LPF0, B4DXI3, E7EU16, P22966, Q53YX9, Q59GY8, Q7M4L4
UniProt Entry Name	ACE_HUMAN
KEGG	hsa:1636
String	9606.ENSP00000290866
Molecular Weight	Calculated MW: 150 kDa
Buffer	Ascites containing 0.09% sodium azide.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Angiotensin I Converting Enzyme (ACE)

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