This product is currently in development. The lead time for this product may be several months. Please contact us at
[email protected] for an updated lead time before purchasing this product.
This product is currently in development. The lead time for this product may be several months. Please contact us at
[email protected] for an updated lead time before purchasing this product.
BRAF is involved in the transduction of mitogenic signals from the cell membrane to the nucleus. It may play a role in the postsynaptic responses of hippocampal neuron. Defects in BRAF are a cause of cardiofaciocutaneous syndrome (CFC syndrome), also known as cardio-facio-cutaneous syndrome. CFC syndrome is characterized by a distinctive facial appearance, heart defects and mental retardation. Heart defects include pulmonic stenosis, atrial septal defects and hypertrophic cardiomyopathy. Some affected individuals present with ectodermal abnormalities such as sparse, friable hair, hyperkeratotic skin lesions and a generalized ichthyosis-like condition. Typical facial features are similar to Noonan syndrome. They include high forehead with bitemporal constriction, hypoplastic supraorbital ridges, downslanting palpebral fissures, a depressed nasal bridge, and posteriorly angulated ears with prominent helices. The inheritance of CFC syndrome is autosomal dominant.
Target |
B-Raf Proto Oncogene Serine/Threonine Protein Kinase Phospho-Thr439 (BRAF pT439) |
Clonality |
Polyclonal |
Target Modification |
Thr439 |
Modification |
Phosphorylation |
Reactivity |
Human |
Tested Applications |
ELISA, DB |
Host |
Rabbit |
Recommended dilutions |
DB: 1/500. Optimal dilutions/concentrations should be determined by the end user. |
Conjugation |
Unconjugated |
Immunogen |
KLH-conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding T439 of human BRAF. |
Isotype |
IgG |
Form |
Liquid |
Purification |
Purified by protein A affinity chromatography. Then, the antibody fraction was peptide affinity purified in a 2-step procedure with peptides. The antibody was eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS. |
Storage |
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
UniProt Primary AC |
P15056 (UniProt,
ExPASy)
|
UniProt Entry Name |
BRAF_HUMAN |
KEGG |
hsa:673
|
String |
9606.ENSP00000288602
|
Molecular Weight |
Calculated MW: 84.4 kDa |
Buffer |
PBS containing 0.09% sodium azide. |
Specificity |
Predicted to react with Chicken BRAF. |
Availability |
Please enquire. |
Note |
This product is for research use only. |
Research Articles on B-Raf Proto Oncogene Serine/Threonine Protein Kinase Phospho-Thr439 (BRAF pT439)