B-Raf Proto Oncogene Serine/Threonine Protein Kinase Phospho-Thr439 (BRAF pT439) Antibody

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Catalogue No: abx031938
Price: US$326.25
(Size: 80 µl)

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This product is currently in development. The lead time for this product may be several months. Please contact us at [email protected] for an updated lead time before purchasing this product.

This product is currently in development. The lead time for this product may be several months. Please contact us at [email protected] for an updated lead time before purchasing this product.

BRAF is involved in the transduction of mitogenic signals from the cell membrane to the nucleus. It may play a role in the postsynaptic responses of hippocampal neuron. Defects in BRAF are a cause of cardiofaciocutaneous syndrome (CFC syndrome), also known as cardio-facio-cutaneous syndrome. CFC syndrome is characterized by a distinctive facial appearance, heart defects and mental retardation. Heart defects include pulmonic stenosis, atrial septal defects and hypertrophic cardiomyopathy. Some affected individuals present with ectodermal abnormalities such as sparse, friable hair, hyperkeratotic skin lesions and a generalized ichthyosis-like condition. Typical facial features are similar to Noonan syndrome. They include high forehead with bitemporal constriction, hypoplastic supraorbital ridges, downslanting palpebral fissures, a depressed nasal bridge, and posteriorly angulated ears with prominent helices. The inheritance of CFC syndrome is autosomal dominant.

Target B-Raf Proto Oncogene Serine/Threonine Protein Kinase Phospho-Thr439 (BRAF pT439)
Clonality Polyclonal
Target Modification Thr439
Modification Phosphorylation
Reactivity Human
Tested Applications ELISA, DB
Host Rabbit
Recommended dilutions DB: 1/500. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen KLH-conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding T439 of human BRAF.
Isotype IgG
Form Liquid
Purification Purified by protein A affinity chromatography. Then, the antibody fraction was peptide affinity purified in a 2-step procedure with peptides. The antibody was eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC P15056 (UniProt, ExPASy)
UniProt Entry Name BRAF_HUMAN
KEGG hsa:673
String 9606.ENSP00000288602
Molecular Weight Calculated MW: 84.4 kDa
Buffer PBS containing 0.09% sodium azide.
Specificity Predicted to react with Chicken BRAF.
Availability Please enquire.
Note This product is for research use only.
Research Articles on B-Raf Proto Oncogene Serine/Threonine Protein Kinase Phospho-Thr439 (BRAF pT439)


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