This product is currently in development. The lead time for this product may be several months. Please contact us at
[email protected] for an updated lead time before purchasing this product.
This product is currently in development. The lead time for this product may be several months. Please contact us at
[email protected] for an updated lead time before purchasing this product.
DAXX is proposed to mediate activation of the JNK pathway and apoptosis via MAP3K5 in response to signaling from TNFRSF6 and TGFBR2. Interaction with HSPB1/HSP27 may prevent interaction with TNFRSF6 and MAP3K5 and block DAXX-mediated apoptosis. In contrast, in lymphoid cells JNC activation and TNFRSF6-mediated apoptosis may not involve DAXX. DAXX seems to regulate transcription in PML/POD/ND10 nuclear bodies together with PML and may influence TNFRSF6-dependent apoptosis thereby. This protein down-regulates basal and activated transcription, and it also seems to act as a transcriptional co-repressor and inhibits PAX3 and ETS1 through direct protein-protein interaction. DAXX modulates PAX5 activity. Its transcription repressor activity is modulated by recruiting it to subnuclear compartments like the nucleolus or PML/POD/ND10 nuclear bodies through interactions with MCSR1 and PML, respectively.
Target |
DAXX (pS671) |
Clonality |
Polyclonal |
Target Modification |
Ser671 |
Modification |
Phosphorylation |
Reactivity |
Human |
Tested Applications |
ELISA, DB |
Host |
Rabbit |
Recommended dilutions |
DB: 1/500. Optimal dilutions/concentrations should be determined by the end user. |
Conjugation |
Unconjugated |
Immunogen |
KLH-conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S671 of human DAXX. |
Isotype |
IgG |
Form |
Liquid |
Purification |
Purified through a protein A column, followed by two-step phosphospecific peptide affinity purification. |
Storage |
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
UniProt Primary AC |
Q9UER7 (UniProt,
ExPASy)
|
UniProt Entry Name |
DAXX_HUMAN |
String |
9606.ENSP00000363668
|
Molecular Weight |
Calculated MW: 81.4 kDa |
Buffer |
PBS containing 0.09% sodium azide. |
Availability |
Please enquire. |
Note |
This product is for research use only. |
Research Articles on DAXX (pS671)