3-Hydroxyanthranilate 3,4-Dioxygenase (HAAO) Antibody

HAAO Antibody is a Rabbit Polyclonal antibody against HAAO. 3-Hydroxyanthranilate 3,4-dioxygenase is a monomeric cytosolic protein belonging to the family of intramolecular dioxygenases containing nonheme ferrous iron. It is widely distributed in peripheral organs, such as liver and kidney, and is also present in low amounts in the central nervous system. HAAO catalyzes the synthesis of quinolinic acid (QUIN) from 3-hydroxyanthranilic acid. QUIN is an excitotoxin whose toxicity is mediated by its ability to activate glutamate N-methyl-D-aspartate receptors. Increased cerebral levels of QUIN may participate in the pathogenesis of neurologic and inflammatory disorders. HAAO has been suggested to play a role in disorders associated with altered tissue levels of QUIN.

Target	3-Hydroxyanthranilate 3,4-Dioxygenase (HAAO)
Clonality	Polyclonal
Reactivity	Mouse, Rat
Tested Applications	WB
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Recombinant fusion protein containing a sequence corresponding to amino acids 1-286 of human HAAO.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P46952 (UniProt, ExPASy)
UniProt Secondary AC	A6NE56, B4DIN2, Q53QZ7, Q8N6N9
UniProt Entry Name	3HAO_HUMAN
Gene Symbol	HAAO
GeneID	23498
NCBI Accession	NP_036337.2
KEGG	hsa:23498
String	9606.ENSP00000294973
Molecular Weight	Calculated MW: 33 kDa Observed MW: 32 kDa
Buffer	PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on 3-Hydroxyanthranilate 3,4-Dioxygenase (HAAO)

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