Tyrosine-Protein Kinase ABL1 (ABL1) Antibody

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Catalogue No: abx011613
Price: US$420.50
(Size: 100 µl)

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Datasheet SDS
The Tyrosine-Protein Kinase ABL1 (ABL1) protooncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns Tyrosine-Protein Kinase ABL1 (ABL1) into an oncogene. The t (9;22) translocation results in the head-to-tail fusion of the BCR (MIM:151410) and Tyrosine-Protein Kinase ABL1 (ABL1) genes present in many cases of chronic myelogeneous leukemia. The DNA-binding activity of the ubiquitously expressed Tyrosine-Protein Kinase ABL1 (ABL1) tyrosine kinase is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function for Tyrosine-Protein Kinase ABL1 (ABL1). The Tyrosine-Protein Kinase ABL1 (ABL1) gene is expressed as either a 6- or 7-kb mRNA transcript, with alternatively spliced first exons spliced to the common exons 2-11./ABL2 is a cytoplasmic tyrosine kinase which is closely related to but distinct from Tyrosine-Protein Kinase ABL1 (ABL1). The similarity of the proteins includes the tyrosine kinase domains and extends amino-terminal to include the SH2 and SH3 domains. ABL2 is expressed in both normal and tumor cells. The ABL2 gene product is expressed as two variants bearing different amino termini, both approximately 12-kb in length.

Target Tyrosine-Protein Kinase ABL1 (ABL1)
Clonality Monoclonal
Reactivity Human
Tested Applications ELISA
Host Mouse
Recommended dilutions ELISA: 1/10000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen Purified recombinant fragment of ABL1 (aa577-650) expressed in E. coli.
Isotype IgG1
Form Liquid
Purification Unpurified ascites.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC P00519 (UniProt, ExPASy)
UniProt Secondary AC A3KFJ3, Q13869, Q13870, Q16133, Q17R61, Q45F09
UniProt Entry Name ABL1_HUMAN
Gene Symbol ABL1
GeneID 25
OMIM 189980
HGNC 76
KEGG hsa:25
Ensembl ENSG00000097007
String 9606.ENSP00000361423
Molecular Weight 122 kDa
Buffer Ascitic fluid containing 0.03% sodium azide.
Concentration Not determined.
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on Tyrosine-Protein Kinase ABL1 (ABL1)


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