Activin Receptor Type IA Antibody

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Catalogue No: abx033178
Price: US$290.00
(Size: 80 µl)

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Datasheet SDS
Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. ACVR1 is an activin A type I receptor which signals a particular transcriptional response in concert with activin type II receptors.

Target Activin Receptor Type IA
Clonality Polyclonal
Reactivity Human
Tested Applications ELISA, WB, IHC
Host Rabbit
Recommended dilutions WB: 1/1000, IHC-P: 1/50 - 1/100. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen KLH-conjugated synthetic peptide between 138-170 amino acids from the Central region of human Activin Receptor Type IA (ACVR1).
Isotype IgG
Form Liquid
Purification Purified Rabbit Polyclonal Antibody.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC Q04771 (UniProt, ExPASy)
UniProt Entry Name ACVR1_HUMAN
KEGG hsa:90
String 9606.ENSP00000263640
Molecular Weight Calculated MW: 57.2 kDa
Buffer PBS containing 0.09% sodium azide.
Specificity Predicted to react with Mouse, Rat and Cow ACVR1.
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on Activin Receptor Type IA


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