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BCR (pY177) Antibody

Catalogue No: abx000257
Price: £220.00
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BCR (pY177) Antibody

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BCR (pY177) Antibody is a Rabbit Polyclonal antibody against BCR (pY177). A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac. Two transcript variants encoding different isoforms have been found for this gene.

Target BCR (pY177)
Clonality Polyclonal
Reactivity Human, Mouse
Tested Applications WB, IHC
Host Rabbit
Recommended dilutions WB: 1/500 - 1/2000, IHC: 1/50 - 1/100. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen Synthetic Peptide. A phospho specific peptide corresponding to residues surrounding Y177 of human BCR.
Isotype IgG
Form Liquid
Purification Affinity purified.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC P11274 (UniProt, ExPASy)
UniProt Secondary AC P78501, Q12842, Q4LE80, Q6NZI3
UniProt Entry Name BCR_HUMAN
Gene Symbol BCR
GeneID 613
KEGG hsa:61
String 9606.ENSP00000303507
Molecular Weight Calculated MW: 137 kDa, 142 kDa
Observed MW: 143 kDa
Buffer PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
Concentration > 1 mg/ml
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on BCR (pY177) Antibody

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