Osteocalcin (Osteocalcin) Antibody

Catalogue No: abx001288
Price: £260.00
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Osteocalcin Antibody is a Rabbit Polyclonal antibody against Osteocalcin. Bone g-carboxyglutamic acid (Gla) protein, known as BGLAP, BGP or osteocalcin, is an abundant, non-collagenous protein component of bone that is produced by osteoblasts. In mice, osteocalcin is composed of a cluster of 3 genes known as OG1, OG2 and ORG, all of which can be found within a 23Kb span of genomic DNA. Human osteocalcin is a highly conserved, 46-50 amino acid, single chain protein that contains three vitamin K-dependent g-carboxyglutamic acid residues. Osteocalcin appears transiently in embryonic bone at the time of mineral deposition, where it binds to hydroxyapatite in a calcium-dependent manner. In addition, osteocalcin is one of the most abundant, non-collagenous proteins found in mineralized adult bone. Genetic variation at the osteocalcin locus on chromosome 1q impacts postmenopause bone mineral density (BMD) levels and may predispose some women to osteoporosis.

Target Osteocalcin
Clonality Polyclonal
Reactivity Human
Tested Applications WB, IHC
Host Rabbit
Recommended dilutions WB: 1/200 - 1/500, IHC: 1/50 - 1/100. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen A synthetic peptide of human BGLAP.
Isotype IgG
Form Liquid
Purification Affinity purified.
Storage Aliquot and store at 2°C to 8°C upon receipt.
UniProt Primary AC P02818 (UniProt, ExPASy)
UniProt Secondary AC Q5TCK6
UniProt Entry Name OSTCN_HUMAN
Gene Symbol BGLAP
GeneID 632
KEGG hsa:63
String 9606.ENSP00000357255
Molecular Weight Calculated MW: 10 kDa
Observed MW: 11 kDa
Buffer PBS, pH 7.3, 0.02% sodium azide.
Concentration > 1 mg/ml
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on Osteocalcin (Osteocalcin) Antibody

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