Menu

BRCA1 (pS1524) Antibody

Catalogue No: abx000365
Price: £220.00
Reviews: 0 reviews
(0 reviews)

Click on the image to see the image legend

Available Options

* Size:



BRCA1 (pS1524) Antibody is a Rabbit Polyclonal antibody against BRCA1 (pS1524). This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified.

Target BRCA1 (pS1524)
Clonality Polyclonal
Reactivity Human
Tested Applications IHC
Host Rabbit
Recommended dilutions IHC: 1/50 - 1/100. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen Synthetic Peptide. A phospho specific peptide corresponding to residues surrounding S1524 of human BRCA1.
Isotype IgG
Form Liquid
Purification Affinity purified.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC P38398 (UniProt, ExPASy)
UniProt Secondary AC E9PFZ0, O15129, Q1RMC1, Q3LRJ0, Q3LRJ6, Q6IN79, Q7KYU9
UniProt Entry Name BRCA1_HUMAN
Gene Symbol BRCA1
GeneID 672
KEGG hsa:67
String 9606.ENSP00000418960
Molecular Weight Calculated MW: 7 kDa, 78-85 kDa, 202-210 kDa
Buffer PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
Concentration > 1 mg/ml
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on BRCA1 (pS1524) Antibody

Write a review

Your Name
Your Email Address
PMID
DOI
Type
Your Review

Note: HTML is not translated!

Rating Bad Good


Tags:
(Click to show)