Caspase 3 active Antibody

Catalogue No: abx200557
Price: £200.00
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Caspase 3 active Antibody is a Rabbit Polyclonal against Caspase 3 active.

Caspases are a family of cytosolic aspartate specific cysteine proteases involved in apoptosis and inflammation. Caspase-3 (CPP-32, Apoptain, Yama, SCA-1) is a key protease that is activated during the early stages of apoptosis, as it is either partially or totally responsible for the proteolytic cleavage of many key proteins during apoptosis, such as ply (APD-ribose) polymerase (PARP). The processed form of Caspase 3 consists of large (17kDa) and small (12kDa) subunits which is derived from the 32 kDa proenzyme and associate to form an active enzyme. Caspase 3 is cleaved at Asp28 Ser29 and Asp175 Ser176. The active Caspase 3 proteolytically cleaves and activates other caspases (e.g. Caspases 6, 7 and 9).

Target Caspase 3 active
Reactivity Human
Host Rabbit
Clonality Polyclonal
Tested Applications WB
Recommended dilutions WB: 1/3000. Optimal dilutions/concentrations should be determined by the end user.
Immunogen Synthetic peptide (KLH-conjugated) corresponding to amino terminal residues adjacent to Asp175 of human caspase-3.
Purity > 90%
Conjugation Unconjugated
Specificity The antibody preferentially recognizes the p17 fragment of the active Caspase-3, and Cleaved Caspase-3 (Asp175).
Storage Aliquoted and store in the dark at - 20 °C. Avoidrepeated freeze/thaw cycles.
Molecular Weight 17 kDa
Swiss Prot P42574
GeneID 836
Concentration 3 mg/ml
Buffer 20 mM PBS, 150 mM CINa, pH 7.2, 0.09% sodium azide. Does not contain BSA.
Availability Shipped within 3-5 working days.
Note This product is for research use only.

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