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CBL (pY700) Antibody

Catalogue No: abx000343
Price: £220.00
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CBL (pY700) Antibody CBL (pY700) Antibody

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CBL (pY700) Antibody is a Rabbit Polyclonal antibody against CBL (pY700). This gene is a proto-oncogene that encodes a RING finger E3 ubiquitin ligase. The encoded protein is one of the enzymes required for targeting substrates for degradation by the proteasome. This protein mediates the transfer of ubiquitin from ubiquitin conjugating enzymes (E2) to specific substrates. This protein also contains an N-terminal phosphotyrosine binding domain that allows it to interact with numerous tyrosine-phosphorylated substrates and target them for proteasome degradation. As such it functions as a negative regulator of many signal transduction pathways. This gene has been found to be mutated or translocated in many cancers including acute myeloid leukaemia. Mutations in this gene are also the cause of Noonan syndrome-like disorder.

Target CBL (pY700)
Clonality Polyclonal
Reactivity Human
Tested Applications WB, IHC, IF/ICC
Host Rabbit
Recommended dilutions WB: 1/500 - 1/1000, IHC: 1/50 - 1/100, IF/ICC: 1/20 - 1/100. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen Synthetic Peptide. A phospho specific peptide corresponding to residues surrounding Y700 of human CBL.
Isotype IgG
Form Liquid
Purification Affinity purified.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC P22681 (UniProt, ExPASy)
UniProt Secondary AC A3KMP8
UniProt Entry Name CBL_HUMAN
Gene Symbol CBL
GeneID 867
String 9606.ENSP00000264033
Molecular Weight Calculated MW: 99 kDa
Observed MW: 100 kDa
Buffer PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
Concentration > 1 mg/ml
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on CBL (pY700) Antibody

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