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Protein Tyrosine Phosphatase Receptor Type C / CD45 (PTPRC) Antibody

Catalogue No: abx000698
Price: £260.00
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CD45 Antibody is a Rabbit Polyclonal antibody against CD45. The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported.

Target Protein Tyrosine Phosphatase Receptor Type C / CD45 (PTPRC)
Reactivity Human
Host Rabbit
Clonality Polyclonal
Tested Applications WB, IHC, FCM
Recommended dilutions WB: 1/200 - 1/500, IHC: 1/50 - 1/100, FCM: 1/20 - 1/50. Optimal dilutions/concentrations should be determined by the end user.
Immunogen A synthetic peptide of human CD45.
Purification Affinity purified.
Form Liquid
Isotype IgG
Conjugation Unconjugated
Storage Aliquot and store at 2°C to 8°C upon receipt.
Molecular Weight Calculated MW: 130 kDa, 147 kDa
Observed MW: 150 kDa
Swiss Prot P08575
GeneID 5788
Gene Symbol PTPRC
Concentration > 1 mg/ml
Buffer PBS, pH 7.3, 0.02% sodium azide.
UNSPSC Code 12352203
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on Protein Tyrosine Phosphatase Receptor Type C / CD45 (PTPRC) Antibody

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