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CDKN1A (pT145) Antibody

Catalogue No: abx000375
Price: £220.00
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CDKN1A (pT145) Antibody is a Rabbit Polyclonal antibody against CDKN1A (pT145). This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-CDK2 or -CDK4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen (PCNA), a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of CDK2, and may be instrumental in the execution of apoptosis following caspase activation. Multiple alternatively spliced variants have been found for this gene.

Target CDKN1A (pT145)
Clonality Polyclonal
Reactivity Human
Tested Applications IHC
Host Rabbit
Recommended dilutions IHC: 1/50 - 1/100. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen Synthetic Peptide. A phospho specific peptide corresponding to residues surrounding T145 of human CDKN1A.
Isotype IgG
Form Liquid
Purification Affinity purified.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC P38936 (UniProt, ExPASy)
UniProt Secondary AC Q14010, Q6FI05, Q9BUT4
UniProt Entry Name CDN1A_HUMAN
Gene Symbol CDKN1A
GeneID 1026
String 9606.ENSP00000384849
Molecular Weight Calculated MW: 18 kDa
Buffer PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
Concentration > 1 mg/ml
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on CDKN1A (pT145) Antibody

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