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Cyclin Dependent Kinase Inhibitor 2B (CDKN2B) Antibody

Catalogue No: abx026926
Price: £225.00
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Cyclin Dependent Kinase Inhibitor 2B (CDKN2B) Antibody Cyclin Dependent Kinase Inhibitor 2B (CDKN2B) Antibody Cyclin Dependent Kinase Inhibitor 2B (CDKN2B) Antibody

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This gene lies adjacent to the tumor suppressor gene CDKN2A in a region that is frequently mutated and deleted in a wide variety of tumors. This gene encodes a cyclin-dependent kinase inhibitor, which forms a complex with CDK4 or CDK6, and prevents the activation of the CDK kinases, thus the encoded protein functions as a cell growth regulator that controls cell cycle G1 progression. The expression of this gene was found to be dramatically induced by TGF beta, which suggested its role in the TGF beta induced growth inhibition. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported.

Target CDKN2B
Clonality Polyclonal
Reactivity Human
Tested Applications WB, IHC, IF/ICC, FCM
Host Rabbit
Recommended dilutions Validated in IHC-P and IF. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen KLH-conjugated synthetic peptide between 102-130 amino acids from the C-terminal region of human CDKN2B.
Isotype IgG
Purification Purified through a protein A column, followed by peptide affinity purification.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC P42772 (UniProt, ExPASy)
UniProt Secondary AC O15125, Q6FI09
UniProt Entry Name CDN2B_HUMAN
Gene Symbol CDKN2B
KEGG hsa:1030
String 9606.ENSP00000276925
Buffer PBS containing 0.09% sodium azide.
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on Cyclin Dependent Kinase Inhibitor 2B (CDKN2B) Antibody

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