Complement C3 (C3) Antibody (Biotin)

Complement C3 (C3) Antibody (Biotin) is a Rabbit Polyclonal antibody conjugated to Biotin against Complement C3. C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates. Derived from proteolytic degradation of complement C3, C3a anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes.

Target	Complement C3 (C3)
Clonality	Polyclonal
Reactivity	Mouse
Tested Applications	ELISA
Host	Rabbit
Recommended dilutions	Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Biotin
Immunogen	Recombinant mouse Complement C3 protein (1321-1663AA).
Isotype	IgG
Form	Liquid
Purity	> 95%
Purification	Purified by Protein G.
Storage	Aliquot and store at -20°C. Avoid exposure to light. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P01027 (UniProt, ExPASy)
UniProt Secondary AC	Q61370, Q80XP1
UniProt Entry Name	CO3_MOUSE
Gene Symbol	C3
GeneID	12266
NCBI Accession	NP_033908.2 NM_009778.3
KEGG	mmu:12266
Ensembl	ENSMUSG00000024164
String	10090.ENSMUSP00000024988
Buffer	0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Complement C3 (C3)

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