Catechol O-Methyltransferase (COMT) Antibody

COMT Antibody is a Rabbit Polyclonal antibody against COMT. Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between S-COMT and MB-COMT reside within the N-termini. Several transcript variants are formed through the use of alternative translation initiation sites and promoters. [provided by RefSeq, Sep 2008].

Target	Catechol O-Methyltransferase (COMT)
Clonality	Polyclonal
Reactivity	Human, Mouse
Tested Applications	WB, IP
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/2000, IP: 0.5-4 µg/200-400 µg whole cell extracts. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Recombinant fusion protein containing a sequence corresponding to amino acids 42-221 of human COMT.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P21964 (UniProt, ExPASy)
UniProt Secondary AC	A8MPV9, Q6IB07, Q6ICE6, Q9BWC7
UniProt Entry Name	COMT_HUMAN
Gene Symbol	COMT
GeneID	1312
NCBI Accession	NP_009294.1
KEGG	hsa:1312
String	9606.ENSP00000354511
Molecular Weight	Calculated MW: 30 kDa Observed MW: 25 kDa, 30 kDa
Buffer	PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Catechol O-Methyltransferase (COMT)

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