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Catechol O-Methyltransferase (COMT) Antibody

Catalogue No: abx001179
Price: £120.00
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Catechol O-Methyltransferase (COMT) Antibody

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COMT Antibody is a Rabbit Polyclonal antibody against COMT. Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between S-COMT and MB-COMT reside within the N-termini. Several transcript variants are formed through the use of alternative translation initiation sites and promoters. [provided by RefSeq, Sep 2008].

Target COMT
Clonality Polyclonal
Reactivity Human, Mouse
Tested Applications WB
Host Rabbit
Recommended dilutions WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen Recombinant protein of human COMT.
Isotype IgG
Form Liquid
Purification Affinity purified.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC P21964 (UniProt, ExPASy)
UniProt Secondary AC A8MPV9, Q6IB07, Q6ICE6, Q9BWC7
UniProt Entry Name COMT_HUMAN
Gene Symbol COMT
GeneID 1312
KEGG hsa:1312
String 9606.ENSP00000354511
Molecular Weight Calculated MW: 24 kDa, 30 kDa
Observed MW: 25 kDa, 30 kDa
Buffer PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
Concentration > 1 mg/ml
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on Catechol O-Methyltransferase (COMT) Antibody

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