Transcriptional Repressor CTCF (CTCF) Antibody

Catalogue No: abx000579
Price: £260.00
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CTCF Antibody is a Rabbit Polyclonal antibody against CTCF. Transcriptional insulators are DNA elements that set boundaries on the actions of enhancer and silencer elements and thereby organize the eukaryotic genome into regulatory domains. All vertebrate insulators appear to use the versatile CTCF protein. CTCF uses various combinations of its 11 zinc fingers to recognize a variety of unrelated DNA sequences. Once bound to DNA, CTCF can function as a transcriptional insulator, repressor, or activator, depending on the context of the binding site [PMID:12787766,15454938]. In vertebrates, this 11 zinc-finger protein is shown to be crucial in processes of epigenetic imprinting, X chromosome inactivation, and associated with various complex human diseases including cancer and diabetes [PMID:23139640].

Target CTCF
Clonality Polyclonal
Reactivity Human, Mouse
Tested Applications WB, IHC
Host Rabbit
Recommended dilutions WB: 1/500 - 1/1000, IHC: 1/20 - 1/50. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen Recombinant protein of human CTCF.
Isotype IgG
Form Liquid
Purification Affinity purified.
Storage Aliquot and store at 2°C to 8°C upon receipt.
UniProt Primary AC P49711 (UniProt, ExPASy)
UniProt Secondary AC B5MC38, Q53XI7, Q59EL8
UniProt Entry Name CTCF_HUMAN
Gene Symbol CTCF
GeneID 10664
String 9606.ENSP00000264010
Molecular Weight Calculated MW: 45 kDa, 82 kDa
Observed MW: 150 kDa
Buffer PBS, pH 7.3, 0.02% sodium azide.
Concentration > 1 mg/ml
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on Transcriptional Repressor CTCF (CTCF) Antibody

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