Interleukin 8 Receptor Beta / IL8RB (CXCR2) Antibody

Catalogue No: abx002121
Price: £120.00
(Size: 20 µl)
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CXCR2 Antibody is a Rabbit Polyclonal antibody against CXCR2. The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. This receptor also binds to chemokine (C-X-C motif) ligand 1 (CXCL1/MGSA), a protein with melanoma growth stimulating activity, and has been shown to be a major component required for serum-dependent melanoma cell growth. This receptor mediates neutrophil migration to sites of inflammation. The angiogenic effects of IL8 in intestinal microvascular endothelial cells are found to be mediated by this receptor. Knockout studies in mice suggested that this receptor controls the positioning of oligodendrocyte precursors in developing spinal cord by arresting their migration.

Target Interleukin 8 Receptor Beta / IL8RB (CXCR2)
Clonality Polyclonal
Reactivity Human
Tested Applications WB
Host Rabbit
Recommended dilutions WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen A synthetic peptide of human CXCR2.
Isotype IgG
Form Liquid
Purification Purified by affinity chromatography.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC P25025 (UniProt, ExPASy)
UniProt Secondary AC Q8IUZ1, Q9P2T6, Q9P2T7
UniProt Entry Name CXCR2_HUMAN
Gene Symbol CXCR2
GeneID 3579
KEGG hsa:3579
String 9606.ENSP00000319635
Molecular Weight Calculated MW: 40 kDa
Observed MW: 43 kDa
Buffer PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
Concentration > 0.5 mg/ml
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on Interleukin 8 Receptor Beta / IL8RB (CXCR2)

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