DCX Antibody

Catalogue No: abx000574
Price: £260.00
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DCX Antibody

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DCX Antibody is a Rabbit Polyclonal antibody against DCX. This gene encodes a member of the doublecortin family. The protein encoded by this gene is a cytoplasmic protein and contains two doublecortin domains, which bind microtubules. In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation. The encoded protein appears to direct neuronal migration by regulating the organization and stability of microtubules. In addition, the encoded protein interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetylhydrolase, and this interaction is important to proper microtubule function in the developing cortex. Mutations in this gene cause abnormal migration of neurons during development and disrupt the layering of the cortex, leading to epilepsy, mental retardation, subcortical band heterotopia ("double cortex" syndrome) in females and lissencephaly ("smooth brain" syndrome) in males. Multiple transcript variants encoding different isoforms have been found for this gene.

Target DCX
Reactivity Human, Mouse, Rat
Origin Human
Host Rabbit
Clonality Polyclonal
Tested Applications WB, IHC
Recommended dilutions WB: 1/200 - 1/2000, IHC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Immunogen Recombinant protein of human DCX.
Purification Affinity purified.
Isotype IgG
Conjugation Unconjugated
Storage Aliquot and store at -20 °C. Avoid repeated freeze/thaw cycles.
Molecular Weight 45 kDa
Swiss Prot O43602
GeneID 1641
Gene Symbol DCX
Concentration > 1 mg/ml
Buffer PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Availability Shipped within 5-10 working days.
Note This product is for research use only.

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