Menu

Doublecortin (DCX) Antibody

Catalogue No: abx000574
Price: £260.00
Reviews: 0 reviews
(0 reviews)

Click on the image to see the image legend

Available Options

* Size:


DCX Antibody is a Rabbit Polyclonal antibody against DCX. This gene encodes a member of the doublecortin family. The protein encoded by this gene is a cytoplasmic protein and contains two doublecortin domains, which bind microtubules. In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation. The encoded protein appears to direct neuronal migration by regulating the organization and stability of microtubules. In addition, the encoded protein interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetylhydrolase, and this interaction is important to proper microtubule function in the developing cortex. Mutations in this gene cause abnormal migration of neurons during development and disrupt the layering of the cortex, leading to epilepsy, mental retardation, subcortical band heterotopia ("double cortex" syndrome) in females and lissencephaly ("smooth brain" syndrome) in males. Multiple transcript variants encoding different isoforms have been found for this gene.

Target DCX
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Tested Applications WB, IHC
Recommended dilutions WB: 1/500 - 1/1000, IHC: 1/20 - 1/50. Optimal dilutions/concentrations should be determined by the end user.
Immunogen Recombinant protein of human DCX.
Purification Affinity purified.
Form Liquid
Isotype IgG
Conjugation Unconjugated
Storage Aliquot and store at 2°C to 8°C upon receipt.
Molecular Weight Calculated MW: 40 kDa
Observed MW: 40 kDa
Swiss Prot O43602
GeneID 1641
Gene Symbol DCX
Concentration > 1 mg/ml
Buffer PBS, pH 7.3, 0.02% sodium azide.
UNSPSC Code 12352203
Availability Shipped within 5-10 working days.
Note This product is for research use only.

Write a review

Your Name
Your Email Address
PMID
DOI
Type
Your Review

Note: HTML is not translated!

Rating Bad Good