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DNA Fragmentation Factor Subunit Alpha (DFFA) Antibody

Catalogue No: abx000734
Price: £260.00
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DFFA Antibody is a Rabbit Polyclonal antibody against DFFA. Apoptosis is accompanied by shrinkage and fragmentation of the cells and nuclei and degradation of the chromosomal DNA into nucleosomal units. DNA fragmentation factor (DFF), heterodimer of 40-kDa (DFFB) and 45-kDa (DFFA) subunits, is one of the major endonucleases responsible for internucleosomal DNA cleavage during apoptosis. DFFA is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF activated after cleavage of DFFA by caspase-3 followed by its dissociation from DFFB. DFFB has been found to trigger both DNA fragmentation and chromatin condensation during apoptosis. DFFA appears to be a 45-kDa protein despite the predicated MW of 37 kDa.

Target DFFA
Clonality Polyclonal
Reactivity Human
Tested Applications WB
Host Rabbit
Recommended dilutions WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen Recombinant protein of human DFFA.
Isotype IgG
Form Liquid
Purification Affinity purified.
Storage Aliquot and store at 2°C to 8°C upon receipt.
UniProt Primary AC O00273 (UniProt, ExPASy)
UniProt Secondary AC Q5T6G5, Q5T6G6, Q96I97, Q9Y6C6
UniProt Entry Name DFFA_HUMAN
Gene Symbol DFFA
GeneID 1676
String 9606.ENSP00000366237
Molecular Weight Calculated MW: 29 kDa, 36 kDa
Observed MW: 45 kDa
Buffer PBS, pH 7.3, 0.02% sodium azide.
Concentration > 1 mg/ml
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on DNA Fragmentation Factor Subunit Alpha (DFFA) Antibody

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