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Extracellular Matrix Protein 1 (ECM1) Antibody

Catalogue No: abx001274
Price: £220.00
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ECM1 Antibody is a Rabbit Polyclonal antibody against ECM1. ECM1 (extracellular matrix protein 1), also known as secretory component p85, is a secreted glycoprotein that is essential for the proper structure and function of the skin. It is widely expressed and localizes to the extracellular matrix. ECM1 binds to a variety of extracellular matrix components, including Perlecan, Fibulin and matrix metalloproteinase-9 (MMP-9), and participates in the structural organization of the dermis. In addition, ECM1 enhances the association of Collagen Type IV with Laminin 332 suggesting that it is a key player in interstitial dermis and the dermal-epidermal junction. Mutations in the gene encoding ECM1 result in the autosomal recessive disorder lipoid proteinosis (LiP). LiP is characterized by hyalinization of the dermis and reduplication of the basement membrane of the skin. LiP patients exhibit thickening of the skin and mucosae. Four splice variants (known as ECM1a-ECM1d) exist for ECM1.

Target ECM1
Clonality Polyclonal
Reactivity Human, Mouse, Rat
Tested Applications WB, IHC
Host Rabbit
Recommended dilutions WB: 1/500 - 1/1000, IHC: 1/50 - 1/100. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen Recombinant protein corresponding to human ECM1.
Isotype IgG
Form Liquid
Purification Affinity purified.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC Q16610 (UniProt, ExPASy)
UniProt Entry Name ECM1_HUMAN
Gene Symbol ECM1
GeneID 1893
String 9606.ENSP00000358045
Molecular Weight Calculated MW: 19 kDa, 46 kDa, 60 kDa, 63 kDa
Observed MW: 50 kDa
Buffer PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
Concentration 2.11 mg/ml
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on Extracellular Matrix Protein 1 (ECM1) Antibody

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