EIF2S1 (pS51) Antibody

EIF2S1 (pS51) Antibody is a Rabbit Polyclonal antibody against EIF2S1 (pS51). The translation initiation factor EIF2 catalyzes the first regulated step of protein synthesis initiation, promoting the binding of the initiator tRNA to 40S ribosomal subunits. Binding occurs as a ternary complex of methionyl-tRNA, EIF2, and GTP. EIF2 is composed of 3 nonidentical subunits, the 36-kD EIF2-alpha subunit (EIF2S1), the 38-kD EIF2-beta subunit (EIF2S2; MIM 603908), and the 52-kD EIF2-gamma subunit (EIF2S3; MIM 300161). The rate of formation of the ternary complex is modulated by the phosphorylation state of EIF2-alpha (Ernst et al., 1987.

Target	EIF2S1 (pS51)
Clonality	Polyclonal
Reactivity	Human, Rat
Tested Applications	WB
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	A synthetic phosphorylated peptide around S51 of human EIF2S1.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P05198 (UniProt, ExPASy)
UniProt Entry Name	IF2A_HUMAN
Gene Symbol	EIF2S1
GeneID	1965
NCBI Accession	NP_004085.1
KEGG	hsa:1965
String	9606.ENSP00000256383
Molecular Weight	Calculated MW: 36 kDa Observed MW: 38 kDa
Buffer	PBS, pH 7.3, containing 0.05% Proclin-300, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on EIF2S1 (pS51)

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