ERBB2 (pY1221 / Y1222) Antibody

Catalogue No: abx000201
Price: £220.00
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ERBB2 (pY1221/Y1222) Antibody is a Rabbit Polyclonal antibody against ERBB2 (pY1221/Y1222). This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized.

Target ERBB2 (pY1221/Y1222)
Clonality Polyclonal
Reactivity Human
Tested Applications WB
Host Rabbit
Recommended dilutions WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen Synthetic Peptide. A phospho specific peptide corresponding to residues surrounding Y1221/Y1222 of human ERBB2.
Isotype IgG
Form Liquid
Purification Affinity purified.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC P04626 (UniProt, ExPASy)
UniProt Secondary AC B2RZG3, B4DHN3, Q14256, Q6LDV1, Q9UMK4, X5D2V5
UniProt Entry Name ERBB2_HUMAN
Gene Symbol ERBB2
GeneID 2064
KEGG hsa:206
String 9606.ENSP00000269571
Molecular Weight Calculated MW: 62 kDa, 70 kDa, 97 kDa, 134 kDa, 136 kDa, 137 kDa
Observed MW: 190 kDa
Buffer PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
Concentration > 1 mg/ml
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on ERBB2 (pY1221 / Y1222) Antibody

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