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FAS-Associated Death Domain Protein (FADD) Antibody

Catalogue No: abx000849
Price: £260.00
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FADD Antibody is a Rabbit Polyclonal antibody against FADD. The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development.

Target FADD
Clonality Polyclonal
Reactivity Human
Tested Applications WB
Host Rabbit
Recommended dilutions WB: 1/500 - 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen Recombinant fusion protein of human FADD.
Isotype IgG
Form Liquid
Purification Affinity purified.
Storage Aliquot and store at 2°C to 8°C upon receipt.
UniProt Primary AC Q13158 (UniProt, ExPASy)
UniProt Secondary AC Q14866, Q6IBR4
UniProt Entry Name FADD_HUMAN
Gene Symbol FADD
GeneID 8772
KEGG hsa:877
String 9606.ENSP00000301838
Molecular Weight Calculated MW: 23 kDa
Observed MW: 23 kDa
Buffer PBS, pH 7.3, 0.02% sodium azide.
Concentration > 1 mg/ml
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on FAS-Associated Death Domain Protein (FADD) Antibody

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