FMS Like Tyrosine Kinase 3 (FLT3) Antibody

Catalogue No: abx000548
Price: £260.00
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FLT3 Antibody is a Rabbit Polyclonal antibody against FLT3. This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. This receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia.

Target FLT3
Reactivity Human
Host Rabbit
Clonality Polyclonal
Tested Applications WB, IHC
Recommended dilutions WB: 1/500 - 1/1000, IHC: 1/50 - 1/100. Optimal dilutions/concentrations should be determined by the end user.
Immunogen Recombinant fusion protein of human FLT3.
Purification Affinity purified.
Form Liquid
Isotype IgG
Conjugation Unconjugated
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Molecular Weight Calculated MW: 108 kDa/112 kDa
Observed MW: 120 kDa
Swiss Prot P36888
GeneID 2322
Gene Symbol FLT3
Concentration 1.90 mg/ml
Buffer PBS with 0.02% sodium azide, 50% glycerol, pH 7.3.
UNSPSC Code 12352203
Availability Shipped within 5-10 working days.
Note This product is for research use only.

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