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Glutamate Decarboxylase 2 (GAD2) Antibody

Catalogue No: abx000857
Price: £260.00
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Glutamate Decarboxylase 2 (GAD2) Antibody is a Rabbit Polyclonal antibody against Glutamate Decarboxylase 2 (GAD2). This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantibody and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Alternative splicing results in multiple transcript variants that encode the same protein.

Target Glutamate Decarboxylase 2 (GAD2)
Clonality Polyclonal
Reactivity Human
Tested Applications WB, IHC, IF/ICC
Host Rabbit
Recommended dilutions WB: 1/500 - 1/1000, IHC: 1/50 - 1/100, IF/ICC: 1/20 - 1/50. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen A synthetic peptide of human GAD2.
Isotype IgG
Form Liquid
Purification Affinity purified.
Storage Aliquot and store at 2°C to 8°C upon receipt.
UniProt Primary AC Q05329 (UniProt, ExPASy)
UniProt Secondary AC Q9UD87
UniProt Entry Name DCE2_HUMAN
Gene Symbol GAD2
GeneID 2572
OMIM 138275
NCBI Accession NM_000818.2 NM_001134366.1
HGNC 4093
KEGG hsa:257
Ensembl ENSG00000136750
String 9606.ENSP00000365437
Molecular Weight Calculated MW: 65 kDa
Observed MW: 65 kDa
Buffer PBS, pH 7.3, 0.02% sodium azide.
Concentration > 1 mg/ml
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on Glutamate Decarboxylase 2 (GAD2) Antibody

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