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Glucokinase (GCK) Antibody

Catalogue No: abx000717
Price: £120.00
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GCK Antibody is a Rabbit Polyclonal antibody against GCK. Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. Alternative splicing of this gene results in three tissue-specific forms of glucokinase, one found in pancreatic islet beta cells and two found in liver. The protein localizes to the outer membrane of mitochondria. In contrast to other forms of hexokinase, this enzyme is not inhibited by its product glucose-6-phosphate but remains active while glucose is abundant. Mutations in this gene have been associated with non-insulin dependent diabetes mellitus (NIDDM), maturity onset diabetes of the young, type 2 (MODY2) and persistent hyperinsulinemic hypoglycemia of infancy (PHHI).

Target GCK
Clonality Polyclonal
Reactivity Human
Tested Applications IF/ICC
Host Rabbit
Recommended dilutions IF/ICC: 1/20 - 1/100. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen Recombinant fusion protein of human GCK.
Isotype IgG
Form Liquid
Purification Affinity purified.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC P35557 (UniProt, ExPASy)
UniProt Secondary AC A4D2J2, A4D2J3, Q05810
UniProt Entry Name HXK4_HUMAN
Gene Symbol GCK
GeneID 2645
KEGG hsa:264
String 9606.ENSP00000223366
Molecular Weight Calculated MW: 52 kDa
Buffer PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
Concentration > 1 mg/ml
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on Glucokinase (GCK) Antibody

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