Guanine Nucleotide Binding Protein (G Protein), Alpha Activating Activity Polypeptide O (GNAO1) Antibody

GNAO1 Antibody is a Rabbit Polyclonal antibody against GNAO1. Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein contains an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand-receptor binding results in detachment of the G protein, switching it to an 'on' state and permitting Galpha activation of second messenger signalling cascades. There are several types of Galpha proteins; Galphas and Galphai bind directly to adenylyl cyclase and stimulate or inhibit its activity, leading to an increase or decrease in cAMP levels respectively.

Target	Guanine Nucleotide Binding Protein (G Protein), Alpha Activating Activity Polypeptide O (GNAO1)
Clonality	Polyclonal
Reactivity	Human, Mouse, Rat
Tested Applications	WB, IF/ICC
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/2000, IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Recombinant fusion protein containing a sequence corresponding to amino acids 60-180 of human GNAO1.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P09471 (UniProt, ExPASy)
UniProt Secondary AC	P29777, Q8TD72, Q9UMV4
UniProt Entry Name	GNAO_HUMAN
Gene Symbol	GNAO1
GeneID	2775
NCBI Accession	NP_066268.1
KEGG	hsa:2775
String	9606.ENSP00000262494
Molecular Weight	Calculated MW: 40 kDa Observed MW: 39 kDa
Buffer	PBS, pH 7.3, containing 0.01% thimerosal, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Guanine Nucleotide Binding Protein (G Protein), Alpha Activating Activity Polypeptide O (GNAO1)

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