Transmembrane Glycoprotein NMB (GPNMB) Antibody

The protein encoded by this gene is a type I transmembrane glycoprotein which shows homology to the pMEL17 precursor, a melanocyte-specific protein.GPNMB shows expression in the lowly metastatic human melanoma cell lines and xenografts but does not show expression in the highly metastatic cell lines.GPNMB may be involved in growth delay and reduction of metastatic potential.Two transcript variants encoding different isoforms have been found for this gene.

Target	Transmembrane Glycoprotein NMB (GPNMB)
Clonality	Monoclonal
Reactivity	Human
Tested Applications	ELISA, WB, IHC
Host	Mouse
Recommended dilutions	ELISA: 1/10000, WB: 1/500 - 1/2000, IHC: 1/200 - 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Purified recombinant fragment of human GPNMB (AA: 31-260) expressed in E. coli.
Isotype	IgG1
Form	Liquid
Purification	Purified from ascites by Protein G chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q14956 (UniProt, ExPASy)
UniProt Secondary AC	A4D155, Q6UVX1, Q8N1A1
Gene Symbol	GPNMB
GeneID	10457
OMIM	604368
HGNC	4462
Ensembl	ENSG00000136235
Molecular Weight	64 kDa
Buffer	PBS, containing 0.05% sodium azide.
Concentration	1 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Transmembrane Glycoprotein NMB (GPNMB)

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