Heterogeneous Nuclear Ribonucleoprotein A1 (HNRNPA1) Antibody

Catalogue No: abx002041
Price: £230.00
(Size: 50 µl)
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Heterogeneous Nuclear Ribonucleoprotein A1 (HNRNPA1) Antibody

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HNRNPA1 Antibody is a Rabbit Polyclonal antibody against HNRNPA1. This gene belongs to the A/B subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind to RNAs. It is one of the most abundant core proteins of hnRNP complexes and it is localized to the nucleoplasm. This protein, along with other hnRNP proteins, is exported from the nucleus, probably bound to mRNA, and is immediately re-imported. Its M9 domain acts as both a nuclear localization and nuclear export signal. The encoded protein is involved in the packaging of pre-mRNA into hnRNP particles, transport of poly A+ mRNA from the nucleus to the cytoplasm, and may modulate splice site selection. It is also thought have a primary role in the formation of specific myometrial protein species in parturition. Multiple alternatively spliced transcript variants have been found for this gene but only two transcripts are fully described. These variants have multiple alternative transcription initiation sites and multiple polyA sites.

Target HNRNPA1
Clonality Polyclonal
Reactivity Human, Mouse, Pig
Tested Applications WB, IHC
Host Rabbit
Recommended dilutions WB: 1/500 - 1/1000, IHC: 1/50 - 1/100. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen Recombinant fusion protein of human HNRNPA1.
Isotype IgG
Form Liquid
Purification Affinity purified.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC P09651 (UniProt, ExPASy)
UniProt Secondary AC A8K4Z8, Q3MIB7, Q6PJZ7
UniProt Entry Name ROA1_HUMAN
Gene Symbol HNRNPA1
GeneID 3178
KEGG hsa:3178
String 9606.ENSP00000341826
Molecular Weight Calculated MW: 29 kDa, 34 kDa, 38 kDa
Observed MW: 33 kDa
Buffer PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
Concentration > 1 mg/ml
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on Heterogeneous Nuclear Ribonucleoprotein A1 (HNRNPA1) Antibody

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