PTEN (pS380 / T382 / T383) Antibody

Catalogue No: abx000193
Price: £220.00
Reviews: 0 reviews
(0 reviews)

Click on the image to see the image legend

Available Options

* Size:



PTEN (pS380/T382/T383) Antibody is a Rabbit Polyclonal antibody against PTEN (pS380/T382/T383). Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine-phosphorylated proteins. Also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-diphosphate, phosphatidylinositol 3-phosphate and inositol 1,3,4,5-tetrakisphosphate with order of substrate preference in vitro PtdIns(3,4,5)P3 > PtdIns(3,4)P2 > PtdIns3P > Ins(1,3,4,5)P4. The lipid phosphatase activity is critical for its tumor suppressor function. Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival. The unphosphorylated form cooperates with AIP1 to suppress AKT1 activation. Dephosphorylates tyrosine-phosphorylated focal adhesion kinase and inhibits cell migration and integrin-mediated cell spreading and focal adhesion formation. May be a negative regulator of insulin signaling and glucose metabolism in adipose tissue.

Target PTEN (pS380/T382/T383)
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Tested Applications WB, IHC, IF/ICC
Recommended dilutions WB: 1/500 - 1/1000, IHC: 1/50 - 1/100, IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Immunogen Synthetic Peptide. A phospho specific peptide corresponding to residues surrounding S380/T382/T383 of human PTEN.
Purification Affinity purified.
Form Liquid
Isotype IgG
Conjugation Unconjugated
Storage Aliquot and store at -20 °C. Avoid repeated freeze/thaw cycles.
Molecular Weight Calculated MW: 19 kDa/47 kDa/64 kDa
Observed MW: 55 kDa
Swiss Prot P60484
GeneID 5728
Gene Symbol PTEN
Enzyme Commission Number EC 3.1.3.16, EC 3.1.3.67, EC 3.1.3.48
Concentration > 1 mg/ml
Buffer PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
UNSPSC Code 12352203
Availability Shipped within 5-10 working days.
Note This product is for research use only.

Write a review

Your Name
Your Email Address
PMID
DOI
Type
Your Review

Note: HTML is not translated!

Rating Bad Good


Tags:
(Click to show)