ERBB3 (pY1328) Antibody

Catalogue No: abx000328
Price: £220.00
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ERBB3 (pY1328) Antibody is a Rabbit Polyclonal antibody against ERBB3 (pY1328). This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized.

Target ERBB3 (pY1328)
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Tested Applications WB, IHC, IF/ICC
Recommended dilutions WB: 1/500 - 1/1000, IHC: 1/50 - 1/100, IF/ICC: 1/100 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Immunogen Synthetic Peptide. A phospho specific peptide corresponding to residues surrounding Y1328 of human ERBB3.
Purification Affinity purified.
Form Liquid
Isotype IgG
Conjugation Unconjugated
Storage Aliquot and store at -20 °C. Avoid repeated freeze/thaw cycles.
Molecular Weight Calculated MW: 20 kDa/36 kDa/77 kDa/141 kDa/148 kDa
Observed MW: 200 kDa
Swiss Prot P21860
GeneID 2065
Gene Symbol ERBB3
Concentration > 1 mg/ml
Buffer PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
UNSPSC Code 12352203
Availability Shipped within 5-10 working days.
Note This product is for research use only.

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