PTEN (pS380) Antibody

Catalogue No: abx000483
Price: £220.00
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PTEN (pS380) Antibody

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PTEN (pS380) Antibody is a Rabbit Polyclonal antibody against PTEN (pS380). This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway.

Target PTEN (pS380)
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Tested Applications IHC, IF/ICC
Recommended dilutions IHC: 1/50 - 1/200, IF/ICC: 1/100 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Immunogen Synthetic Peptide. A phospho specific peptide corresponding to residues surrounding S380 of human PTEN.
Purification Affinity purified.
Form Liquid
Isotype IgG
Conjugation Unconjugated
Storage Aliquot and store at -20 °C. Avoid repeated freeze/thaw cycles.
Molecular Weight Calculated MW: 19 kDa/47 kDa/64 kDa
Swiss Prot P60484
GeneID 5728
Gene Symbol PTEN
Enzyme Commission Number EC 3.1.3.16, EC 3.1.3.67, EC 3.1.3.48
Concentration > 1 mg/ml
Buffer PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
UNSPSC Code 12352203
Availability Shipped within 5-10 working days.
Note This product is for research use only.

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