INSR (pY1151) / IGF1R (pY1136) Antibody is a Rabbit Polyclonal antibody against INSR (pY1151) / IGF1R (pY1136). Type I insulin-like growth factor receptor (IGF-IR) is a transmembrane receptor tyrosine kinase that is widely expressed in many cell lines and cell types within fetal and postnatal tissues. Receptor autophosphorylation follows binding of the IGF-I and IGF-II ligands. Three tyrosine residues within the kinase domain (Tyr1131, Tyr1135, and Tyr1136) are the earliest major autophosphorylation sites. Phosphorylation of these three tyrosine residues is necessary for kinase activation. Insulin receptors (IRs) share significant structural and functional similarity with IGF-I receptors, including the presence of an equivalent tyrosine cluster (Tyr1146/1150/1151) within the kinase domain activation loop. Tyrosine autophosphorylation of IRs is one of the earliest cellular responses to insulin stimulation. Autophosphorylation begins with phosphorylation at Tyr1146 and either Tyr1150 or Tyr1151, while full kinase activation requires triple tyrosine phosphorylation.
Research Articles on INSR (pY1151) / IGF1R (pY1136) Antibody
||INSR (pY1151) / IGF1R (pY1136)
||Human, Mouse, Rat
||WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.
||Synthetic Peptide. A phospho specific peptide corresponding to residues surrounding Y1190 of human Insulin Receptor beta.
||Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
|UniProt Primary AC
||Calculated MW: 154 kDa, 155 kDa, 156 kDa
Observed MW: Refer to Figures
||PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
||> 1 mg/ml
||Shipped within 5-10 working days.
||This product is for research use only.