Integrin Alpha IIb / CD41 (ITGA2B) Antibody

ITGA2B Antibody is a Rabbit Polyclonal antibody against ITGA2B. ITGA2B encodes integrin alpha chain 2b. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 2b undergoes post-translational cleavage to yield disulfide-linked light and heavy chains that join with beta 3 to form a fibronectin receptor expressed in platelets that plays a crucial role in coagulation. Mutations that interfere with this role result in thrombasthenia. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling.

Target	Integrin Alpha IIb / CD41 (ITGA2B)
Clonality	Polyclonal
Reactivity	Human, Mouse
Tested Applications	WB
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Recombinant fusion protein containing a sequence corresponding to amino acids 693-993 of human CD41/CD41/ITGA2B.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P08514 (UniProt, ExPASy)
UniProt Secondary AC	B2RCY8, O95366, Q14443, Q17R67
UniProt Entry Name	ITA2B_HUMAN
Gene Symbol	ITGA2B
GeneID	3674
NCBI Accession	NP_000410.2
KEGG	hsa:3674
String	9606.ENSP00000262407
Molecular Weight	Calculated MW: 113 kDa Observed MW: 135 kDa
Buffer	PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Integrin Alpha IIb / CD41 (ITGA2B)

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