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ITGB3 (pY773) Antibody

Catalogue No: abx000420
Price: £220.00
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ITGB3 (pY773) Antibody is a Rabbit Polyclonal antibody against ITGB3 (pY773). Integrin a-V/beta-3 is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin a-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins a-IIb/beta-3 and a-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin a-IIb/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin a-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.

Target ITGB3 (pY773)
Clonality Polyclonal
Reactivity Human, Mouse
Tested Applications WB, IHC
Host Rabbit
Recommended dilutions WB: 1/500 - 1/1000, IHC: 1/50 - 1/100. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen Synthetic Peptide. A phospho specific peptide corresponding to residues surrounding Y773 of human ITGB3.
Isotype IgG
Form Liquid
Purification Affinity purified.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC P05106 (UniProt, ExPASy)
UniProt Secondary AC A0PJW2, D3DXJ8, O15495, Q12806, Q13413, Q14648, Q16499
UniProt Entry Name ITB3_HUMAN
Gene Symbol ITGB3
GeneID 3690
String 9606.ENSP00000452786
Molecular Weight Calculated MW: 86 kDa, 87 kDa
Observed MW: 110 kDa
Buffer PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
Concentration > 1 mg/ml
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on ITGB3 (pY773) Antibody

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