Potassium Intermediate/Small Conductance Calcium-Activated Channel, Subfamily N, Member 3 (KCNN3) Antibody

KCNN3 Antibody is a Rabbit Polyclonal antibody against KCNN3. Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. This gene belongs to the KCNN family of potassium channels. It encodes an integral membrane protein that forms a voltage-independent calcium-activated channel, which is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. This gene contains two CAG repeat regions in the coding sequence. It was thought that expansion of one or both of these repeats could lead to an increased susceptibility to schizophrenia or bipolar disorder, but studies indicate that this is probably not the case. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Target	Potassium Intermediate/Small Conductance Calcium-Activated Channel, Subfamily N, Member 3 (KCNN3)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	WB
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Recombinant fusion protein containing a sequence corresponding to amino acids 237-426 of human KCNN3.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q9UGI6 (UniProt, ExPASy)
UniProt Secondary AC	B1ANX0, O43517, Q86VF9, Q8WXG7
UniProt Entry Name	KCNN3_HUMAN
Gene Symbol	KCNN3
GeneID	3782
NCBI Accession	NP_740752.1
String	9606.ENSP00000481848
Molecular Weight	Calculated MW: 81 kDa Observed MW: 82 kDa
Buffer	PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Potassium Intermediate/Small Conductance Calcium-Activated Channel, Subfamily N, Member 3 (KCNN3)

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