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Melanocyte-Stimulating Hormone Receptor (MC1R) Antibody

Catalogue No: abx002182
Price: £120.00
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Melanocyte-Stimulating Hormone Receptor (MC1R) Antibody

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MC1R Antibody is a Rabbit Polyclonal antibody against MC1R. This intronless gene encodes the receptor protein for melanocyte-stimulating hormone (MSH). The encoded protein, a seven pass transmembrane G protein coupled receptor, controls melanogenesis. Two types of melanin exist: red pheomelanin and black eumelanin. Gene mutations that lead to a loss in function are associated with increased pheomelanin production, which leads to lighter skin and hair color. Eumelanin is photoprotective but pheomelanin may contribute to UV-induced skin damage by generating free radicals upon UV radiation. Binding of MSH to its receptor activates the receptor and stimulates eumelanin synthesis. This receptor is a major determining factor in sun sensitivity and is a genetic risk factor for melanoma and non-melanoma skin cancer.

Target MC1R
Clonality Polyclonal
Reactivity Human, Mouse
Tested Applications WB
Host Rabbit
Recommended dilutions WB: 1/1000 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen A synthetic peptide of human MC1R.
Isotype IgG
Form Liquid
Purification Affinity purified.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC Q01726 (UniProt, ExPASy)
UniProt Entry Name MSHR_HUMAN
Gene Symbol MC1R
GeneID 4157
KEGG hsa:4157
String 9606.ENSP00000451605
Molecular Weight Calculated MW: 34 kDa
Observed MW: 37 kDa
Buffer PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
Concentration > 1 mg/ml
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on Melanocyte-Stimulating Hormone Receptor (MC1R) Antibody

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