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Minichromosome Maintenance Deficient 4 (MCM4) Antibody

Catalogue No: abx002188
Price: £120.00
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Minichromosome Maintenance Deficient 4 (MCM4) Antibody Minichromosome Maintenance Deficient 4 (MCM4) Antibody Minichromosome Maintenance Deficient 4 (MCM4) Antibody Minichromosome Maintenance Deficient 4 (MCM4) Antibody Minichromosome Maintenance Deficient 4 (MCM4) Antibody Minichromosome Maintenance Deficient 4 (MCM4) Antibody Minichromosome Maintenance Deficient 4 (MCM4) Antibody Minichromosome Maintenance Deficient 4 (MCM4) Antibody Minichromosome Maintenance Deficient 4 (MCM4) Antibody Minichromosome Maintenance Deficient 4 (MCM4) Antibody

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MCM4 Antibody is a Rabbit Polyclonal antibody against MCM4. The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 6 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of this protein by CDC2 kinase reduces the DNA helicase activity and chromatin binding of the MCM complex. This gene is mapped to a region on the chromosome 8 head-to-head next to the PRKDC/DNA-PK, a DNA-activated protein kinase involved in the repair of DNA double-strand breaks. Alternatively spliced transcript variants encoding the same protein have been reported.

Target MCM4
Clonality Polyclonal
Reactivity Human, Mouse, Rat
Tested Applications WB, IHC
Host Rabbit
Recommended dilutions WB: 1/500 - 1/2000, IHC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen A synthetic peptide of human MCM4.
Isotype IgG
Form Liquid
Purification Affinity purified.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC P33991 (UniProt, ExPASy)
UniProt Secondary AC Q8NEH1, Q99658
UniProt Entry Name MCM4_HUMAN
Gene Symbol MCM4
GeneID 4173
KEGG hsa:4173
String 9606.ENSP00000262105
Molecular Weight Calculated MW: 96 kDa
Observed MW: 105 kDa
Buffer PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
Concentration > 1 mg/ml
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on Minichromosome Maintenance Deficient 4 (MCM4) Antibody

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