MUTYH Antibody is a Rabbit Polyclonal antibody against MUTYH. This gene encodes a DNA glycosylase involved in oxidative DNA damage repair. The enzyme excises adenine bases from the DNA backbone at sites where adenine is inappropriately paired with guanine, cytosine, or 8-oxo-7,8-dihydroguanine, a major oxidatively damaged DNA lesion. The protein is localized to the nucleus and mitochondria. Mutations in this gene result in heritable predisposition to colon and stomach cancer. Multiple transcript variants encoding different isoforms have been found for this gene.
| Target |
MUTYH |
| Clonality |
Polyclonal |
| Reactivity |
Human, Rat |
| Tested Applications |
IHC, IF/ICC |
| Host |
Rabbit |
| Recommended dilutions |
IHC: 1/50 - 1/200, IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation |
Unconjugated |
| Immunogen |
Recombinant protein of human MUTYH. |
| Isotype |
IgG |
| Form |
Liquid |
| Purification |
Affinity purified. |
| Storage |
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC |
Q9UIF7 (UniProt,
ExPASy)
|
| UniProt Secondary AC |
D3DPZ4, Q15830, Q9UBP2, Q9UBS7, Q9UIF4, Q9UIF5, Q9UIF6 |
| UniProt Entry Name |
MUTYH_HUMAN |
| Gene Symbol |
MUTYH |
| GeneID |
4595
|
| String |
9606.ENSP00000361170
|
| Molecular Weight |
Calculated MW: 57 kDa, 58 kDa, 59 kDa, 60 kDa |
| Buffer |
PBS, pH 7.3, 0.02% sodium azide, 50% glycerol. |
| Concentration |
> 1 mg/ml |
| Availability |
Shipped within 5-10 working days. |
| Note |
This product is for research use only. |
Research Articles on MutY Homolog (MUTYH) Antibody
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