Bifunctional Heparan Sulfate N-Deacetylase/N-Sulfotransferase 1 (NDST1) Antibody

NDST1 is an essential bifunctional enzyme that catalyzes both the N-deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA dissacharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Plays a role in determining the extent and pattern of sulfation of heparan sulfate. Compared to other NDST enzymes, its presence is absolutely required. Participates in biosynthesis of heparan sulfate that can ultimately serve as L-selectin ligands, thereby playing a role in inflammatory response.

Target	Bifunctional Heparan Sulfate N-Deacetylase/N-Sulfotransferase 1 (NDST1)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, WB, IHC
Host	Rabbit
Recommended dilutions	WB: 1/1000, IHC-P: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 820-849 amino acids from the C-terminal region of human NDST1.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein A column, followed by peptide affinity purification.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P52848 (UniProt, ExPASy)
UniProt Secondary AC	Q96E57
UniProt Entry Name	NDST1_HUMAN
KEGG	hsa:3340
String	9606.ENSP00000261797
Molecular Weight	Calculated MW: 101 kDa
Buffer	PBS containing 0.09% sodium azide.
Specificity	Predicted to react with Mouse and Rat NDST1.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Bifunctional Heparan Sulfate N-Deacetylase/N-Sulfotransferase 1 (NDST1)

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