p16-INK4A (pS140) Antibody

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Catalogue No: abx031883
Price: US$326.25
(Size: 80 µl)

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Datasheet SDS
p16-INK4A functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, MDM1, a protein responsible for the degradation of p53. This protein acts as a negative regulator of the proliferation of normal cells by interacting strongly with CDK4 and CDK6. This inhibits their ability to interact with cyclins D and to phosphorylate the retinoblastoma protein. The gene for this protein is frequently mutated or deleted in a wide variety of tumors, and is known to be an important tumor suppressor gene.

Target p16-INK4A (pS140)
Clonality Polyclonal
Target Modification Ser140
Modification Phosphorylation
Reactivity Human
Tested Applications ELISA, WB, IHC
Host Rabbit
Recommended dilutions WB: 1/1000, IHC-P: 1/50 - 1/100. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen KLH-conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S140 of human p16-INK4A.
Isotype IgG
Form Liquid
Purification Purified by protein G affinity chromatography. Then, the antibody fraction was peptide affinity purified in a 2-step procedure with control and phosphorylated peptides. The phospho-specific antibody was eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC P42771 (UniProt, ExPASy)
UniProt Entry Name CDN2A_HUMAN
NCBI Accession NP_000068.1 NP_001182061.1 NP_478104.2
KEGG hsa:1029
String 9606.ENSP00000418915
Molecular Weight Calculated MW: 16.5 kDa
Buffer PBS containing 0.09% sodium azide.
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on p16-INK4A (pS140)


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