PAK1/2/3 (pT423/402/421) Antibody

Catalogue No: abx000472
Price: £220.00
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PAK1/2/3 (pT423/402/421) Antibody
PAK1/2/3 (pT423/402/421) Antibody

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PAK1/2/3 (pT423/402/421) Antibody is a Rabbit Polyclonal antibody against PAK1/2/3 (pT423/402/421). The activated kinase acts on a variety of targets. Likely to be the GTPase effector that links the Rho-related GTPases to the JNK MAP kinase pathway. Activated by CDC42 and RAC1. Involved in dissolution of stress fibers and reorganization of focal complexes. Involved in regulation of microtubule biogenesis through phosphorylation of TBCB. Activity is inhibited in cells undergoing apoptosis, potentially due to binding of CDC2L1 and CDC2L2.

Target PAK1/2/3 (pT423/402/421)
Reactivity Human, Mouse, Rat
Origin Human
Host Rabbit
Clonality Polyclonal
Tested Applications IHC, IF/ICC
Recommended dilutions IHC: 1/50 - 1/100, IF/ICC: 1/100 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Immunogen Synthetic Peptide. A phospho specific peptide corresponding to residues surrounding T423/402/421 of human PAK1/2/3.
Purification Affinity purified.
Isotype IgG
Conjugation Unconjugated
Storage Aliquot and store at -20 °C. Avoid repeated freeze/thaw cycles.
Swiss Prot Q13153 Q13177 O75914
GeneID 5058/ 5062/ 5063
Gene Symbol PAK1, PAK2, PAK3
Concentration > 1 mg/ml
Buffer PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Availability Shipped within 5-10 working days.
Note This product is for research use only.

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