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PAK1 / 2 / 3 (pT423 / 402 / 421) Antibody

Catalogue No: abx000472
Price: £220.00
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PAK1 / 2 / 3 (pT423 / 402 / 421) Antibody

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PAK1/2/3 (pT423/402/421) Antibody is a Rabbit Polyclonal antibody against PAK1/2/3 (pT423/402/421). The activated kinase acts on a variety of targets. Likely to be the GTPase effector that links the Rho-related GTPases to the JNK MAP kinase pathway. Activated by CDC42 and RAC1. Involved in dissolution of stress fibers and reorganization of focal complexes. Involved in regulation of microtubule biogenesis through phosphorylation of TBCB. Activity is inhibited in cells undergoing apoptosis, potentially due to binding of CDC2L1 and CDC2L2.

Target PAK1/2/3 (pT423/402/421)
Clonality Polyclonal
Reactivity Human, Mouse, Rat
Tested Applications IHC, IF/ICC
Host Rabbit
Recommended dilutions IHC: 1/50 - 1/100, IF/ICC: 1/100 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen Synthetic Peptide. A phospho specific peptide corresponding to residues surrounding T423/402/421 of human PAK1/2/3.
Isotype IgG
Form Liquid
Purification Affinity purified.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC Q13153 (UniProt, ExPASy) Q13177 (UniProt, ExPASy) O75914 (UniProt, ExPASy)
Gene Symbol PAK1, PAK2, PAK3
GeneID 5058/ 5062/ 5063
Molecular Weight Calculated MW: 60 kDa, 61 kDa, 58 kDa, 62 kDa, 64 kDa
Buffer PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
Concentration > 1 mg/ml
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on PAK1 / 2 / 3 (pT423 / 402 / 421) Antibody

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