Serine/Threonine-Protein Kinase PAK 4 (PAK4) Antibody

PAK4 Antibody is a Rabbit Polyclonal antibody against PAK4. PAK proteins, a family of serine/threonine p21-activating kinases, include PAK1, PAK2, PAK3 and PAK4. PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. They serve as targets for the small GTP binding proteins Cdc42 and Rac and have been implicated in a wide range of biological activities. PAK4 interacts specifically with the GTP-bound form of Cdc42Hs and weakly activates the JNK family of MAP kinases. PAK4 is a mediator of filopodia formation and may play a role in the reorganization of the actin cytoskeleton. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

Target	Serine/Threonine-Protein Kinase PAK 4 (PAK4)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	WB
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Recombinant fusion protein containing a sequence corresponding to amino acids 120-280 of human PAK4.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	O96013 (UniProt, ExPASy)
UniProt Secondary AC	B4DGG6, Q8N4E1, Q8NCH5, Q8NDE3, Q9BU33, Q9ULS8
UniProt Entry Name	PAK4_HUMAN
Gene Symbol	PAK4
GeneID	10298
NCBI Accession	NP_005875.1
KEGG	hsa:10298
String	9606.ENSP00000469413
Molecular Weight	Calculated MW: 64 kDa Observed MW: 70 kDa
Buffer	PBS, pH 7.3, containing 0.01% thimerosal, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Serine/Threonine-Protein Kinase PAK 4 (PAK4)

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