Paired Box Protein Pax-6 (PAX6) Antibody

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Catalogue No: abx015955
Price: US$420.50
(Size: 100 µl)

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Datasheet SDS
Transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas.Required for the differentiation of pancreatic islet alpha cells.PAX6 is the most researched of the PAX genes and appears throughout the literature as a "master control" gene for the development of eyes and other sensory organs, certain neural and epidermal tissues as well as other homologous structures, usually derived from ectodermal tissues.This transcription factor is most famous for its use in the interspecifically induced expression of ectopic eyes and is of medical importance because heterozygous mutants produce a wide spectrum of ocular defects such as Aniridia in humans.This gene encodes paired box gene 6, one of many human homologues of the Drosophila melanogaster gene prd.In addition to the hallmark feature of this gene family, a conserved paired box domain, the encoded protein also contains a homeo box domain.Both domains are known to bind DNA, and function as regulators of gene transcription.This gene is expressed in the developing nervous system, and in developing eyes.Mutations in this gene are known to cause aniridia as well as Peter's anomaly, both ocular diseases.

Target Paired Box Protein Pax-6 (PAX6)
Clonality Monoclonal
Reactivity Human
Tested Applications ELISA, FCM
Host Mouse
Recommended dilutions ELISA: 1/10000, FCM: 1/200 - 1/400. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen Purified recombinant fragment of human PAX6 expressed in E. coli.
Isotype IgG1
Form Liquid
Purification Unpurified ascites.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC P26367 (UniProt, ExPASy)
UniProt Secondary AC Q6N006, Q99413
UniProt Entry Name PAX6_HUMAN
Gene Symbol PAX6
GeneID 5080
OMIM 106210
HGNC 8620
KEGG hsa:5080
Ensembl ENSG00000007372
String 9606.ENSP00000404100
Molecular Weight 46 kDa
Buffer Ascitic fluid containing 0.03% sodium azide.
Concentration Not determined.
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on Paired Box Protein Pax-6 (PAX6)


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